Recherche en endocrinologie et diabète

Xanthine Oxidase is Variably Involved in Nutritional and Physio-Pathologic Oxidative Stress Situations

Christine Feillet-Coudray, Gilles Fouret, B?atrice Bonafos, Manar Aoun, Julie Carillon, Thibault Sutra, Caroline Laurent, Jean Max Rouanet, Dominique Lacan, Jean Paul Cristol and Charles Coudray

Xanthine Oxidase is Variably Involved in Nutritional and Physio-Pathologic Oxidative Stress Situations

High random ROS production leads to generalised oxidative stress that is involved in aging and degenerative diseases, such diabetes or chronic kidney failure. The major cellular ROS sources are mitochondria and NADPH oxidase, and xanthine oxidase (XO). XO is known to be involved in ischemiareperfusion oxidative stress damages, but little is known about its possible involvement in other nutritional and physio-pathologic oxidative stress situations.