Recherche en endocrinologie et diabète

Serum Ischemia Modified Albumin as a Marker of Complications in Patients withType 2 DiabetesMellitus

Mahmoud Saleh OF, Nehal Hamdy El Said, Youssef Bahgat HM, El Ghaffar Mohamed NA, Hussein Said El Fishawy and Maha Assem

Background: The term diabetes mellitus describes several diseases of abnormal carbohydrate metabolism that are characterized by hyperglycemia. It is associated with a relative or absolute impairment in insulin secretion along with varying degrees of peripheral resistance to the action of insulin, Type 2 diabetes mellitus is by far the most common type of diabetes in adults (>90 percent), Diabetes is associated with complications such as cardiovascular diseases, retinopathy and neuropathy which can lead to chronic morbidities and mortality, Increased level of oxidative stress markers like malondialdehyde (MDA) has been detected in diabetes associated with complications. Ischemia modified albumin (IMA) is an altered type of serum albumin that forms under conditions of oxidative stress. Increased IMA has been described as a marker of ischemia reperfusion injury and dysfunction of endothelial L-arginine/nitric oxide pathway (affecting NO levels).

Aim of the work: To evaluate serum IMA among diabetic nephropathy, type 2 diabetes mellitus complications in comparison to healthy controls. Results: The serum IMA were higher among group B than group A and group C with P value<0.005 which is statistically significant, there is positive predictive value of serum IMA to detect diabetic nephropathy and other diabetic complications.

Conclusion: There is positive predictive value of serum IMA to detect diabetic complications.