Recherche en endocrinologie et diabète

Hypergastrinaemia and Raised Hydrochloric Acid in Tea Drinking Associated Gastric Ulcer

Jimmy EO, Odeh S, Malachy N and Adelaiye AB

Hypergastrinaemia and Raised Hydrochloric Acid in Tea Drinking Associated Gastric Ulcer

Gastrin levels were observed for 28 days in Lipton tea drinking using high performance liquid chromatography (HPLC). The gastrin concentrations were also observed in the gastric and plasma. Gastric gastrin in rats with gastric ulcer was significantly higher than plasma gastrin in Lipton tea drinking, P<0.05 but rats without gastric ulcer had normal gastrin levels. Rats fed with Lipton tea showed high gastrin and hydrochloric acid secretion as compared with control without Lipton tea drinking; P<0.05. There was marked increase of HCL as the feeding of the rats progressed from day 7 to day 28. The HCL secretion in male rats was not significantly different from the female rats, P >0.05.