Recherche en endocrinologie et diabète

Effect of Clomiphene Citrate on Thyroid Hormones T3, T4 and TSH Levels in Mice Offspring

Wejdan M Henawi and Mohammed O Aljahdali

Infertility can cause considerable social, emotional and psychological stress. Ovulatory dysfunction is one of the most common causes of reproductive failure in sub-fertile and infertile women. There are several approaches to ovulation induction therapy for the management of women with ovulatory disorders. Fertility drugs are spreading worldwide fast and therefore many studies have reviewed the association between the use of these drugs and physiological, biochemical and histopathological alterations. The results of present study showed that there were observed effects of Clomiphene citrate (Clomid)® on albino mice offspring’s hormones level. Treating mothers with CC doses 0.2 and 0.3 mg/day caused significant increasing and variation in males offspring TSH and T3 hormones level only comparing to control and between males & females also of the treated mothers with CC as was clearly noticed. Whereas, the elevations of hormones level was not significant in females offspring of treated mothers with CC.