Journal des troubles du sommeil : traitement et soins

Improved Sleep Quality in Patients Affected by Nocturnal Frontal Lobe Epilepsy (NFLE) Treated with Lacosamide: A Two Cases Report

Mangiardi M and Alfano G

Nocturnal Frontal Lobe Epilepsy (NFLE) is a form of focal epilepsy with heterogeneous clinical presentation of morpheic seizures that tend to cluster overnight, with a good response to carbamazepine (CBZ). We report two cases of NFLE patients associated with sleep disorders, successfully treated with lacosamide 200 mg/day. We hypothesized that lacosamide, in relation to its multiple action mechanisms, can have positive effects not only on seizures control but also on sleep disorders associated with them.