Journal de recherche sur la pharmacie et l'administration de médicaments

Preparation and Evaluation of Ketoprofen Enteric Coated Mini Tablets for Prevention of Chronic Inflammatory Disease

Donthi Mahipalreddy, Dudhipala Narendar, Komalla Devendhar, Suram Dinesh, Sanda Sai Kiran and Banala Nagaraj

Preparation and Evaluation of Ketoprofen Enteric Coated Mini Tablets for Prevention of Chronic Inflammatory Disease

Ketoprofen is the propionic acid derivative used to treat chronic inflammatory disease like rheumatoid/Osteoarthritis. Here, the delivery of the drug based on the mini tablets approach, the few reasons for the mini tablets to avoid the drug release related fluctuations in the body and greater surface area leads to improve the bioavailability when compared with the single tablet dosage form. The tablets were prepared with two different polymers POLYOX WSR and HPMC K4M used individually. The evaluation parameters include preformulation studies, like DSC, solubility and flow properties of powder and post compression evaluation parameters includes hardness, weight variation, content uniformity, Friability, in vitro dissolution, SEM and in vivo radio graphic studies were successfully performed. The tablets were compressed with 3 mm punches by direct compression technique. The results of In vitro release studies of ketoprofen optimized core tablets in pH 6.8 phosphate buffer have shown 98.2% with HPMC K4M and 94% with POLYOX WSR within 12h time period and enteric coated optimized formulation has shown 97.79 ± 1.77. In vivo radio graphic studies showed that the tablets reached the intestinal region within 3 h after administration and was visually observed for 9h in the colonic region after that no tablet was found, total radiographic study was carried out with a single mini tablet due to effect of motility problem.