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An insight into the Role of Epidermal Growth Factor Receptor (EGFR) in Oral Squamous Cell Carcinomas

Ugrappa Sridevi

Despite several advances within the field of medical specialty for
oral cancers, morbidity rate remains high and 5 years survival rate is
moderately improved. Because it is thought that, head and neck
carcinomas square measure sixth most frequent variety of human
cancer globally, among that oral epithelial cell malignant neoplastic
disease is common kind. Role of EGFR has gained abundant vital in
head and neck epithelial cell malignant neoplastic disease as a possible
target for brand new therapies. EGFR consists of associate animate
thing N-terminal ligand-binding domain, a hydrophobic
transmembrane region, associated an intracellular C-terminal amino
alkanoic acid enzyme (TK) domain. The EGFR sequence is mapped to
body 7p11.2 and encodes a 170-kDa transmembrane conjugated
protein. Alterations within the performance of EGFR are coupled with
oncogenic transformation, autonomous cell growth, invasion,
development, and development of metastases in many cancers and
square measure key characteristics of tumors. In recent years, EGFR
has been thought of a promising target for antibody targeted medical
care in conjugation with engineering science. The target of the
presentation is to focus on the importance of EGFR as targeted
medical care for the oral epithelial cell carcinomas.