Journal des nanomatériaux et de la nanotechnologie moléculaire

Nanocarriers Based Oral Insulin Delivery

Lotika Bajaj and Bhupinder Singh Sekhon

Nanocarriers Based Oral Insulin Delivery

Successful oral administration of protein drugs remains an obscure challenge. In this context, oral insulin delivery has always been a significant challenge for pharmaceutical researchers and considerable efforts are being made to deliver insulin orally. Oral insulin therapy seems to have progressed with nanotechnology research, allowing for several types of encapsulations to bypass the gastric acidic environment. Nanoparticles protect insulin against degradation and facilitate the uptake of insulin (associated or not associated to the nanoparticles) through a paracellular or a transcellular pathway. In oral insulin, the mechanism involves various nanoparticle encasings bound to insulin delivery. Continuous comparisons of in vitro and in vivo studies are essential to develop oral insulin delivery systems in near future.