Journal de virologie et de recherche antivirale

Fishing Beyond the Peer: Future Omic Analyses of Virus-Host Interactions

Andrea L. Kroeker, Alicia R. Berard and Kevin M. Coombs

Fishing Beyond the Peer: Future Omic Analyses of Virus-Host Interactions

There has been considerable progress made in the study of viruses and how they infect, replicate and spread inside hosts and host cells. Much is known about how viruses change their genome and proteins throughout their life cycles. However, our understanding of how the host cell itself changes during the virus life cycle is less well developed. Both genomic and proteomic changes are expected to occur during virus propagation, and genomic analyses of the cellular ‘transcriptome’ have been especially fruitful during the past decade. However, our understanding of host protein responses is even more poorly developed. These –omic responses can reflect particular host metabolic pathways, such as immunological strategies, that are ctivated in response to the infecting virus.