Journal de médecine pulmonaire

SARS CoV2 and Gastrointestinal System

Rocao Nayeli Santillain*

COVID-19 (Coronavirus Infectious Disease 2019 is caused by the virus SARS-CoV-2 and it has been a major health public problem worldwide, with complications and more than a million deaths around the world. The virus is part of the Coronaviridae family, and beta coronavirus (β-CoV) genus. Possess several proteins that codify the RNA and takes action in the pathogenesis of the diseases. SARS-CoV-2 can occur as an asymptotic disease or with symptoms like cough, shortness of breath, fever, pneumonia pulmonary edema, severe acute respiratory syndrome (SARS), in some cases neurological and gastrointestinal symptoms even dead.  SARS-CoV-2 has several manifestations, in this review, we collect information for most recent articles about gastrointestinal manifestations, endothelial function, and the molecules involved in it, likewise, sepsis and inflammatory disease, and how the virus can act in that disease.  SARS-CoV2 causes endothelial dysfunction by infection and replication in the endothelial cells, additionally, by inflammatory interleukins release.  Such as sepsis SARS-CoV2 causes coagulopathy disorders; platelet aggregation, micro thrombosis, and severe complications, showing in a dimer D increased, and prothrombin time prolongation.  Therefore, the aim of this article is to collect recent information available about the effect of SARS-CoV2 on different organs, mainly gastrointestinal and endothelial function.