Journal des sciences pharmaceutiques et des médicaments émergents

Preparation Optimization and Evaluation of Okra Mucilage Sodium Alginate Mucoadhesive Composite Beads

Meenakshi Bhatia, Priya Diman and Prerna

The objective of the study is to prepared, optimize and evaluate metformin hydrochloride loaded OM-SA beads as mucoadhesive drug delivery system. The beads were prepared by ionic gelation method using calcium chloride as a cross linker. The prepared formulation was optimized by using 3-factor-3-level central composite design. The synthesized okra, alginate composite beads were characterized by fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy. The results revealed that okra mucilage/alginate, concentrations of calcium chloride and hardening time exerted significant effect on % entrapment, % release rate, % mucoadhesion, %swelling and % yield. Analysis of Variance (ANOVA) was applied on the % entrapment, % Rel24 and % mucoadhesion and %swelling of beads to study the fitting and significance of the model. Ex-vivo mucoadhesion time and in vitro drug release studies revealed that cumulative percent of drug released was found to be 100% over a time period of 24 hr. The prepared beads showed sustain release and used for the treatment of diabetesII.