Journal des sciences pharmaceutiques et des médicaments émergents

Mutation Occurrence in TP53 and Ctnnb1 Genes in Hepatocellular Carcinoma Associated with Echinococcus granulosus Infection

Nazar Sh Mohammed

Echinococcus granulosus is one of the small tap worms that causes Hydatid cyst. This study was planned for detection of the incidence among cancer patients at Tumor unit in Baghdad medical city. A total of 11 samples of liver biopsy have taken from patients with liver cancer in this study. All patients were suffering from Hydatid cyst infection. The present study showed that the predominance of hydatidosis was in the patients whose ages ranged between (≤ 20- 60) years. The majority incidence was recorded between (50-60) years. The study showed that the predominance of hydatidosis was higher in females 28(70%), than males12 (30%). Analysis of the gene sequence showed that there were genetic mutations occurred in the hepatic cells, and several locations underwent change in genetic sequence including TCC to TCT in exon 147(5), GGT to AGT in exon 152(5), ACT to CCT in exon 160(5), TAT to TGT in exon 203(6), ATG to CTG in exon 235(7