Recherche et rapports en gastroentérologie

The Study of Intestinal Permeability and its Relationship with Autism

Menicagli R and Marotta O

Aim: To verify the development of some disorders of Autism by a metabolic alteration in the digestion of some foods for the change of the permeability of the intestinal mucus layer.
Methods: A critical review of the process of the formation of opioidslike peptides produced for an alteration in intestinal permeability able to overcome the encephalic lumen barrier.
Results: Recent studies show that some opioid peptides as the beta-casomorphin-7 pass through the encephalic barrier binding to receptors and inhibiting the normal neuronal transmitter’s reuptake.
Conclusion: The phenomenon of the alteration of the intestinal permeability is always associated with the change in the intestinal mucin expression and with the increasing of the concentration of MUC2 (gel forming). The same phenomenon occurs in the oral mucosa when is present the diabetes; there is an increasing of the excreted mucins MUC7 and MUC5B with a modification of the Spinnbarkeit. The parametric value of mucosal adhesion, with changing its normal continuous layer in a succession of bubbles, separated by channels. So for the similar properties of MUC2 with MUC5B and MUC7,the alteration of intestinal mucosal layer may facilitating the cycle of the opioid peptides and the free radicals formation