Oncologie clinique : rapports de cas

Oxaliplatin-induced Disseminated Intravascular Coagulation. Case report and literature review.

Torrent-Rodriguez*, Bastida C, Lizondo Lopez T, Andres S, Montoya M, Marco-Hernandez J, Tellez A , Maurel J, Castro-Rebollo P, Soy Muner D

Oxaliplatin is a chemotherapy drug commonly used to treat advanced colorectal cancer and other gastrointestinal malignancies as well as refractory lymphomas. However, it can cause a wide range of adverse reactions, including nausea, vomiting, diarrhea, myelosuppression (particularly neutropenia and thrombocytopenia), and mucositis [1]. In some cases, oxaliplatin can also induce other rare hematologic adverse events, such as Thrombotic Micro Angiopathy (TMA) and Disseminated Intravascular Coagulation (DIC) [2]. DIC is a serious condition in which the body's clotting system becomes overactive leading to the formation of small blood clots throughout the body. They can block blood flow to vital organs and consume clotting factors causing systemic haemorrhages. In this case report, we present the case of a 54-year-old female who developed DIC induced by oxaliplatin.