Journal du foie : maladies et transplantation

Sustained Glutathione Deficiency Interferes with the Liver Response to TNF-α and Liver Regeneration after Partial Hepatectomy in Mice

Kimberly J. Riehle, Jamil Haque, Ryan S. McMahan, Terrance J. Kavanagh, Nelson Fausto and Jean S. Campbell

Sustained Glutathione Deficiency Interferes with the Liver Response to TNF-α and Liver Regeneration after Partial Hepatectomy in Mice

Glutathione (GSH) is a tripeptide of glutamate, cysteine, and glycine. It is the most abundant non-protein thiol in the cell, and is present at 5-10 mM in hepatocytes. GSH scavenges reactive oxygen species (ROS) and acts as a cofactor in the metabolism of xenobiotics through reduction and conjugation reactions. Several methods have been used in vivo and in vitro to study the effects of short-term GSH depletion on the hepatocyte cell cycle.